1982年1月8日
硕导
yonghuiwh@btbu.edu.cn
个人简历
教育经历:
2010.01-2012.04,美国纽约大学医学院,环境医学研究所,联合培养博士生
2007.09-2012.07,武汉大学基础医学院,免疫学,博士(硕博连读)
2003.09-2007.07,山东大学,生物技术,学士
工作经历:
2018.09-至今, 北京工商大学,食品与健康学院 副教授
2015.08-2018.08,解放军总医院第一附属医院,全军烧伤研究所, 副研究员
2012.08-2015.07,解放军总医院第一附属医院,全军烧伤研究所, 博士后
主讲课程
食品营养学、基础生物化学、生理学基础、免疫学原理与应用
主要研究领域
围绕全谷物营养健康作用,挖掘谷物新型功能因子,探究mirna等非编码rna参与新型功能因子营养健康作用的分子机制,揭示活性成分防控慢性疾病的分子机理等
主要学术成果(课题、论文、获奖、专利等)
承担的主要科研项目(限5项):
1. 北京市科技新星计划,z181100006218043,mir-30a调控骨骼肌细胞自噬而介导烧伤后骨骼肌消耗的机制研究,2018.01—2020.12, 主持
2. 国家自然科学基金面上项目,81471873,mir-628促进烧伤后胰岛素抵抗和骨骼肌消耗的机制研究,2015.01—2018.12, 主持
3. 北京市自然科学基金面上项目,7172210,mir-181c调控tlr4/nf-κb通路参与烧伤大鼠脓毒症发生的机制研究,2017.01—2019.12, 主持
4. 北京市自然科学基金青年项目,7144250,mir-194参与烧伤后胰岛素抵抗调控的分子机制研究,2014.01—2015.12, 主持
5. 中国博士后基金面上项目,2013m533220,tnfα参与烧伤后骨骼肌蛋白高分解代谢的机制研究,2013.08—2015.08, 主持
发表的代表性论文(限10篇):
1. yu yonghui#; zhang jingjie#; wang jing*; sun baoguo. micrornas: the novel mediators for nutrient-modulating biological functions. trends in food science and technology, 2021, 114: 167-175.
2. yu yonghui#; gaine, goutom kumar#; zhou linyue; zhang jingjie*; wang jing*; sun baoguo. the classical and potential novel healthy functions of rice bran protein and its hydrolysates. critical reviews in food science and nutrition, 2021, 1-13.
3. zhang jingjie, yu yonghui*, wang jing*. protein nutritional support: the classical and potential new mechanisms in the prevention and therapy of sarcopenia. j agric food chem. 2020; 68(14): 4098–4108.
4. yu yonghui#, zhang jingjie#, wang jing*, sun baoguo. the anti-cancer activity and potential clinical application of rice bran extracts and fermentation products. rsc advances, 2019; 9(6): 80060-18069.
5. zhao fen, yu yonghui*, liu wei, liu xinqi*, liu lingying, yin huinan. small molecular weight soybean protein-derived peptides nutriment attenuates rat burn injury-induced muscle atrophy by modulation of ubiquitin-proteasome system and autophagy signaling pathway. j agric food chem. 2018; 66(11): 2724-2734.
6. yu yonghui, yang longlong, han shaofang, wu yushou, liu lingying, chang yang, wang xiaoteng, chai jiake*. mir-190b alleviates cell autophagy and burn-induced skeletal muscle wasting via modulating phlpp1/akt/foxo3a signaling pathway. shock, 2019, 52(5): 513-521..
7. yu yonghui, jin honglei, xu jiheng, gu jiayan, li xin, xie qipeng, huang haishan, li jingxia, tian zhongxian, jiang guosong, chen caiyi, he feng, wu xue-ru, huang chuanshu. xiap overexpression promotes bladder cancer invasion in vitro and lung metastasis in vivo via enhancing nucleolin-mediated rho-gdiβ mrna stability. int j cancer, 2018; 142(10): 2040-2055.
8. yu yonghui #, li xiao #, liu lingying #, chai jiake *, zhang haijun, chu wanli, yin huinan, ma li, duan hongjie, xiao mengjing. mir-628 promotes burn-induced skeletal muscle atrophy via targeting irs1. int j biol sci. 2016; 12(10):1213-1224.
9. li xiao#, liu lingying#, yang jing#, yu yonghui#, chai jiake*, wang lingyan, ma li, yin huinan. exosome derived from human umbilical cord mesenchymal stem cell mediates mir-181c attenuating burn-induced excessive inflammation. ebiomedicine. 2016; 8:72–82.(esi高被引论文)
10. yu yonghui, zhang dongyun, li jingxia, zhang min, wan yu, gao jimin, huang chuanshu*. nf-κb1 p50 promotes p53 protein translation through mir-190 downregulation of phlpp1. oncogene, 2014; 33(8): 996-1005.